Story in Nature Metabolism on our aging project
A new global measure of cell-to-cell transcriptional variability from single-cell RNA-sequencing data has been developed by Levy et al., on the basis of the transcriptional interrelations between genes. The new variable, termed global coordination level, decreases with age in different organisms and cell types and correlates with high mutational load in cells.
Story in Harvard Medical School website on the microbiome project
Insights into the ecology of the microbiome
The microbiome is like a fingerprint: Every person’s community of microbes is complex and unique. But the underlying dynamics of the interactions between microbes that shape these microbial ecosystems may have something in common…
Story in Nature about our microbiome project
Are the dynamics of our microbial communities unique to us or does everyone’s microbiota follow the same rules? The emerging insights into this question could be of relevance to health and disease…
Story in Nature Physics on the microbiome project
Same on the inside
We’ve known for a while that the flora lining our guts can have pronounced effects on our health. And studies like the Human Microbiome Project are fast providing us with the data necessary to put these effects to therapeutic use. But these data attest to the fact that microbial communities are highly variable, and knowing how they interact with their human hosts is essential to the success of new therapies…
Story on our aging project in Phys
Breakdown of gene coordination during aging suggests a substantial challenge to longevity
Using a novel approach from physics, researchers from Bar-Ilan University developed a computational method that quantifies the coordination level between different genes. With this approach, they measured the gene activity of individual cells and compared cells from old and young subjects, discovering phenomena never before observed: old cells lost significant coordination levels compared to young cells…
Story by Nadav Goldberg in Davidson Institute on our aging research – Hebrew
Collaboration for a long life
A new Israeli study finds that the aging process is associated with a decrease in coordination between the different gene groups in cells
One of the biggest open-ended questions in biology today is why we age. More precisely, what causes the function of the cells and tissues in our body to deteriorate over the years, exposing us to diseases and other physiological problems …
Story in Hayad’an website on our aging research – Hebrew
Is aging an orchestra of genes starting to fake?
Dr. Amir Bashan of Bar Ilan University investigates how a process that begins randomly, unplanned and different between different people and even between different cells in the same person, ultimately leads to the same known results?
From the moment the fetus is formed it develops and grows into an adult according to a precise genetic program. Is aging simply a continuation of the same program? Many experts believe not…
Story in “AZO life sciences” website on our aging research
Computational method reveals a new hallmark of aging
While all human beings share analogous changes during aging, like wrinkles, gray hair, and a general drop in function, aging is assumed to be the outcome of a cellular wear-and-tear process caused by accumulated random damage, like structural damage of DNA or genetic modifications